体内分布
体内
纳米颗粒
Zeta电位
胶体金
生物物理学
体外
化学
纳米技术
材料科学
化学工程
生物化学
生物
工程类
生物技术
作者
Ming Xu,Mahmoud G. Soliman,Xing Sun,Beatriz Pelaz,Neus Feliu,Wolfgang J. Parak,Sijin Liu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2018-09-13
卷期号:12 (10): 10104-10113
被引量:112
标识
DOI:10.1021/acsnano.8b04906
摘要
The physicochemical properties of a set of 21 different gold nanoparticles (spherical and rod-shaped nanoparticles (NPs) of different diameters with three different surface coatings) were studied. Protein corona formation, in vitro uptake, effect on cell viability and proliferation, and in vivo biodistribution of these NPs were determined. The relation of the results of the different NPs was analyzed by hierarchical cluster analysis, which will tell which NPs have the most similar physicochemical properties and biological effects, without having to specify individual physicochemical parameters. The results show that the physicochemical properties of gold nanoparticles (Au NPs) are mainly accounted for by their hydrodynamic diameter and their zeta-potential. The formation of the protein corona is determined by the pH-dependence of their zeta-potential. While several reports found that in vitro uptake and in vivo biodistribution of NPs are correlated to individual physicochemical parameters, e. g., size, shape, or surface chemistry, such direct dependence in the investigated multidimensional set of NPs was not found in our study. This most likely is due to entanglement of the different parameters, which complicates the prediction of the biological effect of NPs in case multiple physicochemical properties are simultaneously varied. The in vitro uptake and in vivo biodistribution of NPs seem to be not directly driven by the protein corona, but the physicochemical properties determine as well the corona as they influence in vitro/ in vivo behaviors, and thus the effect of the protein corona would be rather indirect.
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