自身免疫
矽肺
免疫学
医学
免疫系统
炎症体
NALP3
自身免疫性疾病
石棉
抗体
炎症
病理
冶金
材料科学
作者
Sai Peck Lee,Hiroaki Hayashi,Hidenori Mastuzaki,Naoko Kumagai-Τakei,Takemi Otsuki
出处
期刊:Current Opinion in Allergy and Clinical Immunology
[Ovid Technologies (Wolters Kluwer)]
日期:2017-04-01
卷期号:17 (2): 78-84
被引量:54
标识
DOI:10.1097/aci.0000000000000350
摘要
Purpose of review Of the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. Recent findings With respect to silica, many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases. Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown. Silica can activate various immune cells and investigation of the associated imbalance of regulatory T cells, responder T cells as well as Th17 cells might be key in furthering our understanding of silica-induced autoimmune alterations. On the other hand, asbestos exposure shows less association with autoimmune diseases. However, interesting findings pertaining to the detection of antiendothelial and mesothelial cell antibodies in asbestos-exposed patients have been reported. Summary Taken together, further investigations may contribute in delineating the mechanisms involved in environmental factor-induced modification of autoimmunity.
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