Recent Progress of Nucleic Acid Vector Based on Dendritic Polymers

Secure and efficient gene carrier has important application in gene therapy.Compared with viral gene vectors, non-viral gene vector has attracted much attention because of their low immunogenicity, easy mass production and low costs.However, they showed limited activity in transfection efficiency and selectivity.This paper reviewed recent research progress in dendritic polymers gene carriers, including (i) dendritic and derived materials, (ii) supramolecular parent materials, such as the carrier combined with cyclodextrins, and cucurbituril in multivariate and block type pattern, (iii) dendritic polymers gene vector combined with inorganic material, such as gold nanoparticles, iron oxide nanoparticles and graphene, and (iv) functional response type dendritic polymers gene vector, such as the pH response type vector, two disulfide response type vector, redox hyperbranched gene carrier and fluorinated dendrimers as gene vectors.