FOXP3型
Treg细胞
效应器
免疫系统
免疫学
RAR相关孤儿受体γ
平衡
白细胞介素2受体
生物
癌症研究
细胞生物学
医学
T细胞
出处
期刊:Advances in protein chemistry and structural biology
日期:2017-01-01
卷期号:: 155-189
被引量:45
标识
DOI:10.1016/bs.apcsb.2016.10.002
摘要
The balance of CD4+CD25+FOXP3+ regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORγt or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.
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