百万-
生物
突变体
进化生物学
钥匙(锁)
前线(军事)
选择(遗传算法)
突变
生物进化
抗生素耐药性
进化动力学
生态学
遗传学
细菌
地理
基因
计算机科学
社会学
人口学
气象学
人工智能
物理
人口
天文
作者
Michael Baym,Tami D. Lieberman,Eric D. Kelsic,Remy Chait,Rotem Gross,Idan Yelin,Roy Kishony
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-09-09
卷期号:353 (6304): 1147-1151
被引量:434
标识
DOI:10.1126/science.aag0822
摘要
A key aspect of bacterial survival is the ability to evolve while migrating across spatially varying environmental challenges. Laboratory experiments, however, often study evolution in well-mixed systems. Here, we introduce an experimental device, the microbial evolution and growth arena (MEGA)–plate, in which bacteria spread and evolved on a large antibiotic landscape (120 × 60 centimeters) that allowed visual observation of mutation and selection in a migrating bacterial front. While resistance increased consistently, multiple coexisting lineages diversified both phenotypically and genotypically. Analyzing mutants at and behind the propagating front, we found that evolution is not always led by the most resistant mutants; highly resistant mutants may be trapped behind more sensitive lineages. The MEGA-plate provides a versatile platform for studying microbial adaption and directly visualizing evolutionary dynamics.
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