Studies on the Synthesis of Antipyretic Analgesics. V

Having some doubts about the position (N or N′) at which the acyl group is introduced in acylation of N-antipyrinyl-2-methylalanine amide (VIII), reported in the preceding paper, introduction of acyl group was examined in the most simple of the compounds with similar structure N-antipyrinylglycine amide (I). Comparison of infrared spectra of N-acetyl-N-antipyrinylglycine amide (II) and (VIII) proved that acylation of these compounds resulted in introduction of acyl group into N. Haloacylation of (I) Was also proved to give N-substituted compound.