Biosynthesis of Testosterone by Rabbit Testis: Homogenate V Slices.

ICSH in vitro has been shown to increase the production of testosterone by slices of rabbit testis. Homogenate of testis produces approximately the same amount of testosterone as slices stimulated maximally by ICSH when the comparison is made on the same weight of tissue from the same rabbit incubated for the same time. It is considered that these observations support a hypothesis originally proposed for ACTH and its action on the adrenal, namely that a homogenate behaves as though it were stimulated.