Thrombolysis therapy by intravenous administering of urokinase in 128 patients with acute myocardial infarction at elementary hospital

Objectives To investigate the clinical effect of urokinase for treating acute myocardial infarction(AMI).Methods One hundred and twenty eight patients with AMI underwent thrombolysis therapy by intravenous administering of urokinase were enrolled by retrospective analysis.They were assigned to three groups according to the time of morbidity:inner 3 hours group,3 to 6 hours group and 6 to 12 hours group.The recanalization rate after thrombolysis therapy were compared among the 3 groups.Results The total recanalization rate of the 128 cases who received the treatment of urokinase thrombolysis was 71.09%,and no dead case occured.Recanalization rate in inner 3 hours group was significantly higher than those of 3 to 6 hours group[93.33% (28/30) vs.68.49% (50/73),P0.05] and 6 to 12 hours group [93.33% (28/30) vs.52.00% (13/25),P0.05].There were 30 cases (23.43%) with arrhythmias in 2 hours after thrombolysis,and there were 2 case (1.56%) with upper gastrointestinal bleeding,2 case(1.56%)with hypotension and 6 cases(4.68%)with acute heart failure in 24 hours after thrombolysis,respectively.All of them were cured by symptomatic treatments.Conclusions The urokinase in treating AMI is an effective treatment,and it can retrieve the cardiac muscle on the brink of death and improve the prognosis of the patients.