Objective To study the clinical effect of pure titanium frame removable partial dentures.Methods Sixty-two patients have been restored with pure titanium frame removable partial dentures in our hospital,and were revisited during 3 years after restoration.Results Pure titanium frame removable partial dentures were easy to try-in,after3 months and 3 years to visit,patients with partial dentures were satisfied and comfortable,and less denture stomatitis happened.Conclusion Pure titanium frame removable partial denture has better clinical effect for dentition defect.