Following the fast development of space science technology, the data transfer system of spacecraft becomes more and more complex. Traditional multiplexer only supports one or two types of services, and its multiplexing method and scheduling strategy can not be changed during the space mission. Using the advance orbit system suggested by CCSDS, this paper introduces a method to design a reconfigurable multiplexer which supports four types of services and is compatible for three multiplexing methods. The multiplexer’s multiplexing method and scheduling strategy can be reconfigured by the registers which makes the multiplexer high flexible.