反流性食管炎
医学
胃肠病学
幽门螺杆菌
内科学
食管炎
回流
胃炎
消化性
疾病
消化性溃疡
作者
Min‐Ho Park,Soung-Hwan Lee,Sung Hyun Joo,Young-Hae Sohn,Chang-Hwan Park,Wan‐Sik Lee,Young‐Eun Joo,Sung‐Kyu Choi,Jong Sun Rew,Sei-Jong Kim
摘要
Background/Aims: Helicobacter pylori (H. pylori) has been generally accepted as the main etiologic factor in gastrointestinal disease. However, some recent reports suggest a protective role of H. pylori in gastroesophageal reflux disease. We assessed the H. pylori prevalence in reflux esophagitis and development rate of reflux esophagitis after H. pylori eradication. Methods: A total of 398 patients (173 reflux esophagitis patients and 225 chronic gastritis or peptic ulcer patients) from 1998 through 2000 were included in this study. Reflux esophagitis was graded from A to giaccording to the Los Angeles (LA) classification. Among these patients, 86 patients (is cured group and 39 ongoing infection group) underwent H. pylori eradication and subsequent follow-up endoscopy. Results: The rate of H. pylori infection was significantly lower in reflux esophagitis group than in control group (47.3% vs 65.7%, p=0.000l). There was no significant difference in the H. pylori infection rate according to the grade of esophagitis (LA-A 40.3%, LA-B 59.1%, LA-C 50.0%, LA-D 28.6%; p=0.094). After H. pylori eradication therapy, reflux esophagitis was newly developed in 4 cases (8.5%) of cured group and 2 cases (5.1 %) of ongoing infection group. Conclusions: There may be no protective role of H. pylori in reflux esophagitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI