Analysis and evaluation of hyaluronic acid, lamini and tape III procollagen for diagnosis of hepatic carcinoma

Objective To study the change of HA,LN,PCⅢ in the serum of primary hepatic carcinoma and hepatic metastases and the relationship between the hepatic serum fibrosis and hepatic carcinoma or hepatic function index.Methods For the controls(30),primary hepatic carcinoma(28),hepatic metastases(23),hepatic fibrosis serum index including HA,LN,PCⅢ were detected by RIA in 51 primary hepatic carcinoma and hepatic metastases while hepatic carcinoma index including AFP,CEA,Ca-199 were detected by ROSS chemical luminescent immunoassay in 51 serum samples.In addition hepatic function index including AST,ALT,γGT were detected by Backman in 51 serum samples.Results The levels of HA、LN、PCⅢ were found significantly higher in 51 patients than those of the controls.The levels of HA,AFP,hepatic function index were significantly higher in primary hepatic carcinoma than hepatic metastases(P0.01).No significient difference was shown betwwen the level of LN,PCⅢ of primary hepatic carcinoma and hepatic metastases(P0.05).The level of CEA、Ca-199 was remarkable higher in hepatic metastases than primary hepatic carcinoma(P0.05),whereas no significient relationship was found between fibrosis index and carcinoma index or function index.Conclusion Three fibrosis indexes including HA,LN,PCⅢ could well reflect the degree of development of hepatofibrosisin liver carcinoma.However no significant relationship was found between the serum fibrosis index and carcinoma index or function index.