Effect of serrapeptase on postoperative complication of mandibular complicated third molar extraction

Objective: To investigate the ability of serrapeptase to reduce postoperative swelling,pain and trismus after mandibular complicated wisdom teeth extraction.Methods: Sixty patients underwent impacted mandibular third molar extraction were involved and randomly divided into the treatment group which was given serrapeptase 10mg,tid,7d and the control group which was given no serrapeptase.All the patients were given amoxicillin 0.5,tid,3d and metronidazole 0.2,tid,3d to prevent infection.The extent of check swelling,pain and interincisal distance were observed and measured on the 1st,2nd and 7th postoperative days.Results: On the 2nd day after the tooth extraction,the value of swelling in treatment group(9.17±4.17)mm was obviously lower than that of control group(13.97±6.10) mm,with statistically significant difference(P 0.01).The pain score in the serrapeptase group was 2.32±0.98,which showed significant difference(P 0.01) with the pain score of 3.50±1.26 in the control group.However,there was no statistical significant difference between the two groups in trismus(P 0.05).Conclusion: The use of serrapeptase was effective to depress the postoperative negative reactions of the mandibular complicated third molar extraction.