Objective:To observe the curative effect of negative pressure therapy of wound(NPTW)on treating chronic ulcers.Method:NPTW was applied to treat chronic ulcers in 23 cases;growth of granulation tissue and the heal- ing of wounds were observed.Results:Through the period of 2 -8 weeks for treating chronic ulcers in 23 patients with NPTW,wounds got healed directly in 8 cases;necrotic tissues fell off and fresh granulation tissues were observed in 14 ca- ses which were eligible for surgical treating;wound surface diminished,necrotic tissues reduced and infection lessened in 1 patient.The treatment has only slight side effect observed and is easy to be applied.Conclusion:NPTW is a new treat- ment with safe,effective and convenient characteristics in treating chronic ulcers.