Effects of Various Sex Hormones on Excretion of Pregnandiol Early in Pregnancy.

Diethylstilbestrol, testosterone proprionate and progesterone were administered to 15 patients with normal pregnancies in order to study the effect of these substances on progesterone metabolism and pregnandiol excretion. Diethylstilbestrol and testosterone when administered daily in large amounts over long periods during the first 16 weeks of gestation did not alter the normal excretion of pregnandiol. The administration of progesterone was followed by the prompt recovery of a considerable portion of the injected steroid as pregnandiol.