Abstract The sections in this article are: Glycogen Structure Function Pathways of Glycogen Metabolism Overview Glycogen Biosynthesis Glycogen Synthase and Branching Enzyme Glycogenolysis and Debranching Enzyme Glycogen Particles and Physical Interactions among Glycogen‐Metabolizing Proteins Hormonal Regulation of Glycogen Synthesis in Muscle Insulin Mechanisms of Insulin Action Epinephrine Regulation of Glycogen Metabolism in Liver Overview Two Pathways of Glycogen Synthesis in Liver Glucose Transport Is Not Regulated in Liver Regulation of Glucokinase Activity Regulation of Glycogen Synthase Activity Regulation of Glucose‐6‐Phosphatase Activity Regulation of Glycogen Phosphorylase Activity Conclusion