姜黄素
姜黄
根茎
体内
细胞毒性T细胞
体外
细胞毒性
中国仓鼠卵巢细胞
仓鼠
药理学
细胞培养
化学
淋巴瘤
生物
传统医学
生物化学
分子生物学
医学
免疫学
生物技术
遗传学
作者
Ramadasan Kuttan,P. Bhanumathy,K. Nirmala,Mathew George
出处
期刊:Cancer Letters
[Elsevier]
日期:1985-11-01
卷期号:29 (2): 197-202
被引量:570
标识
DOI:10.1016/0304-3835(85)90159-4
摘要
Anticancer activity of the rhizomes of turmeric was evaluated in vitro using tissue culture methods and in vivo in mice using Dalton's lymphoma cells grown as ascites form. Turmeric extract inhibited the cell growth in Chinese Hamster Ovary (CHO) cells at a concentration of 0.4 mg/ml and was cytotoxic to lymphocytes and Dalton's lymphoma cells at the same concentration. Cytotoxic effect was found within 30 min at room temperature (30°C). The active constituent was found to be ‘curcumin’ which showed cytotoxicity to lymphocytes and Dalton's lymphoma cells at a concentration of 4 μg/ml. Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumours.
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