PP135—Pharmacometabolomics for individualized treatment of alcoholism: High serum glutamate level is associated with positive response to acamprosate treatment

Acamprosate, a homo-taurine analogue, is approved for treatment of alcohol dependence. Meta-analyses favor acamprosate for its ability to support abstinence, which is the most stable type of remission in alcoholics. Yet, only a limited number of treatment-seeking alcoholics use acamprosate, most likely because of individual differences in response and the lack of response predictors.