生物
信号肽
蛋白质分选信号
膜
膜蛋白
整体膜蛋白
序列(生物学)
细胞器
肽序列
生物化学
细胞质
细胞生物学
蛋白质靶向
生物物理学
基因
作者
Ulrike Kutay,Enno Hartmann,Tom A. Rapoport
标识
DOI:10.1016/0962-8924(93)90066-a
摘要
Integral membrane proteins are generally targeted to translocation-competent membranes by virtue of signal sequences located close to the N-terminus of the polypeptide chain. Membrane anchoring is caused by the signal sequence or other hydrophobic segments located after it in the amino acid sequence. However, some integral membrane proteins do not follow these rules. The members of one class of nonconformist membrane proteins have no signal sequence, but instead possess a hydrophobic segment near the C-terminus that orients them with their N-termini in the cytoplasm. Members of this class are found in many organelles and are probably inserted into membranes by an unusual mechanism.
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