环十二烷
自行车
化学
组合化学
药物化学
立体化学
有机化学
金属
作者
Wen Yang,Christen M. Giandomenico,Michael Sartori,Dennis A. Moore
标识
DOI:10.1016/s0040-4039(03)00338-1
摘要
An exceptionally high yielding method for the tri-protection of cyclam and cyclen using ethyl trifluoroacetate is described. The selective reaction also applies to the di-protection of 1,4,7-triazacyclononane. The application of this method in the synthesis of AMD3100, a clinical candidate for stem cell mobilization is presented.
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