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生物
蛋白质基因组学
蛋白质组
计算生物学
蛋白质组学
翻译(生物学)
基因组
遗传学
基因组学
基因
肽序列
信使核糖核酸
作者
Shea J. Andrews,Joseph A. Rothnagel
摘要
Short open reading frames (sORFs) are a common feature of all genomes, but their coding potential has mostly been disregarded, partly because of the difficulty in determining whether these sequences are translated. Recent innovations in computing, proteomics and high-throughput analyses of translation start sites have begun to address this challenge and have identified hundreds of putative coding sORFs. The translation of some of these has been confirmed, although the contribution of their peptide products to cellular functions remains largely unknown. This Review examines this hitherto overlooked component of the proteome and considers potential roles for sORF-encoded peptides.
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