乳酸乳球菌
病毒学
生物
免疫系统
免疫
抗原
重组DNA
接种疫苗
病毒
免疫
戊型肝炎病毒
免疫学
微生物学
基因
细菌
乳酸
生物化学
遗传学
基因型
作者
Shandian Gao,Dandan Li,Ying Liu,Enhui Zha,Tiezhong Zhou,Xiqing Yue
标识
DOI:10.1016/j.intimp.2014.10.032
摘要
Hepatitis E virus (HEV) as a recognized zoonotic pathogen has posed global burden on public health, which is exacerbated by lack of efficient vaccine. In this study, we constructed a recombinant (inaQ-ORF2 gene fusion) Lactococcus lactis (L. lactis) strain NZ3900 that expresses and displays the hepatitis E virus antigen ORF2 utilizing an ice uncleation protein-based anchor system. After oral vaccination of BALB/c mice, significantly higher levels of ORF2-specific mucosal IgA and serum IgG were detected and cellular immunity was also induced. These findings further support that L. lactis-based HEV antigen vaccines could be used for human and animal protection against infection.
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