泛发性脓疱性银屑病
医学
白细胞介素
错义突变
白细胞介素1受体拮抗剂
银屑病
受体
细胞因子
免疫学
受体拮抗剂
突变
敌手
内科学
生物
遗传学
基因
作者
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,S. Fraitag,Jihen Zribi,Élodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,H. Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold
标识
DOI：10.1056/nejmoa1013068
摘要
Generalized pustular psoriasis is a life-threatening disease of unknown cause. It is characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein, which may be associated with plaque-type psoriasis.
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