SOX2
前列腺癌
癌症干细胞
医学
干细胞
转移
癌症研究
胚胎干细胞
诱导多能干细胞
表观遗传学
癌症
人口
前列腺
肿瘤科
内科学
生物
遗传学
基因
环境卫生
作者
Candace L. Kerr,Arif Hussain
出处
期刊:Current Opinion in Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2014-05-01
卷期号:26 (3): 328-333
被引量:22
标识
DOI:10.1097/cco.0000000000000080
摘要
Purpose of review Significant advances have been made toward identifying prostate cancer stem cells (CSCs). This review will highlight the latest developments in defining this population and the discovery of mechanisms involved in their survival and metastasis. Recent findings Several groups have identified master regulators of stem cells in prostate cancer. These include genetic and epigenetic factors known to control pluripotency in embryonic stem cells and in highly metastatic prostate tumors. For instance, tumors of patients with poor prognosis demonstrate elevated levels of the pluripotent markers OCT4 and SOX2 as well as the polycomb complex protein Bmi-1 and enhancer of zeste homolog 2. Cells that are derived from these patient tumors provide an opportunity to expand our current knowledge regarding how these cells survive and the mechanisms that regulate their proliferation. Summary Understanding the mechanisms of highly invasive and therapy resistant prostate cancer cells resides in understanding the CSCs, which facilitate cancer recurrence. Some of these factors are just emerging and provide a platform for developing targeted drugs for the future treatment of advanced prostate cancer.
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