血瘀
炎症
医学
增生
血液循环
水肿
药理学
免疫学
病理
传统医学
内科学
中医药
替代医学
作者
Tao Xu,Xiumei Wang,Zhongwei He,Li Yang,Rongrui Wei,Guoyue Zhong,Junwei He
出处
期刊:Brazilian Journal of Pharmaceutical Sciences
[SciELO]
日期:2022-01-01
卷期号:58
被引量:3
标识
DOI:10.1590/s2175-97902021000x32e19359
摘要
Lagopsis supina (Steph) IK.Gal. was a traditional Chinese medicinal plant for promoting blood circulation and removing blood stasis (PBCRBS), anti-inflammatory and diuresis with little scientific validation.The aims of this study were first to evaluate the PBCRBS and anti-inflammatory effects of L. supina in a rat model of traumatic blood stasis (TBS).We demonstrated that an ethanolic extract of L. supina (LS, 460 mg/kg/d) possessed significant PBCRBS and remarkable inhibitory effect on inflammation cytokines, which were associated with renovated amount of the injured muscle fibers, alleviate the degree of the damaged tissue edema, decreased the number of inflammatory cells, increased the number of the capillary hyperplasia by hematoxylin and eosin (HE), as well as remarkably down-regulated (p < 0.05 or p < 0.01) the levels of inflammation cytokines, including TNF-α, IL-6, IL-8, and IL-10 by ELISA.This finding provide a pharmacological basis and partial interpretation for the clinical application of L. supina, which has therapeutic properties for blood stasis syndrome (BSS) and inflammation-related diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI