杨梅素
氧化应激
药理学
炎症
促炎细胞因子
化学
脂多糖
生物化学
内分泌学
内科学
医学
抗氧化剂
槲皮素
山奈酚
作者
Xia Wang,Youpeng Sun,Peixuan Li,Zhikai Wu,Yi-Chun Chen,Yiwu Fu,Hanpeng Wu,Yingrong Ye,Jingjing Wang,Zhengtao Yang,Ershun Zhou
标识
DOI:10.1080/14786419.2022.2089138
摘要
This study aimed to investigate the protective effects and mechanisms of myricetin on acute liver failure in mice induced by lipopolysaccharide (LPS)/D-galactosamine (D-Gal). Our results showed myricetin (25, 50 and 100 mg/kg) pretreatment significantly improved the pathological changes of liver tissues, decreased serum ALT and AST (p < 0.001) induced by LPS/D-GalN. Moreover, MDA and MPO levels were reduced (p < 0.001), CAT and SOD activities were increased (p < 0.001) with myricetin (50 and 100 mg/kg) pretreatment. Likewise, inflammatory cytokines TNF-α and IL-6 mRNA in liver tissues were markedly decreased (p < 0.001) by myricetin. Besides, Nrf2 protein expression was drastically elevated (p < 0.001) by myricetin (25, 50 and 100 mg/kg). All these findings imply that myricetin may protect against acute liver failure by suppressing inflammation and regulating oxidative stress via Nrf2 signaling, and that it may be a possible strategy to avoid liver damage.
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