重性抑郁障碍
遗传力
遗传流行病学
遗传力缺失问题
萧条(经济学)
基因组学
流行病学
精神科
全基因组关联研究
遗传学
医学
生物
遗传变异
基因
基因型
单核苷酸多态性
基因组
心情
病理
经济
宏观经济学
作者
Kimberley Kendall,Evelien Van Assche,Till F. M. Andlauer,Karmel W Choi,Jurjen J. Luykx,Eva C. Schulte,Yi Lu
标识
DOI:10.1017/s0033291721000441
摘要
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders, its high prevalence, moderate heritability, and strong polygenicity have posed major challenges for gene-mapping in MDD. Studies of common genetic variation in MDD, driven by large international collaborations such as the Psychiatric Genomics Consortium, have confirmed the highly polygenic nature of the disorder and implicated over 100 genetic risk loci to date. Rare copy number variants associated with MDD risk were also recently identified. The goal of this review is to present a broad picture of our current understanding of the epidemiology, genetic epidemiology, molecular genetics, and gene-environment interplay in MDD. Insights into the impact of genetic factors on the aetiology of this complex disorder hold great promise for improving clinical care.
科研通智能强力驱动
Strongly Powered by AbleSci AI