Niosomes are vesicular nacarriers that can be used for both amphiphilic and lipophilic drugs. Niosomes are budding vehicles in advanced drug delivery systems. Niosomes are nionic surfactants vesicles that can be formed with or without the addition of cholesterol. Niosomes can be the best choice for nacarriers because of their specific characters like biodegradability, biocompatibility, and immugenic nature. Niosomes can easily trap the hydrophilic and lipophilic drugs and extend the period of the drug in the systemic circulation. Niosomes are the nacarrier that can enhance penetration of drugs into the specific target tissues hence resulting in reduced toxicity. The main aim of this review article is to provide a detailed description of Niosomes.