Bioinformatics of Ubiquitin Domains and Their Binding Partners

This chapter contains sections titled: Introduction The Concept of Functional Domains Bioinformatical Methods for Domain Detection Advantages of Studying Domains in the Ubiquitin System Ubiquitin and Ubiquitin-like Domains Ubiquitin and Related Modifiers The Evolutionary Origin of the Ubiquitin System Ubiquitin Domains in Complex Proteins Other Members of the Ubiquitin Fold Ubiquitin-recognition Domains The Ubiquitin-associated (UBA) Domain The CUE Domain Other UBA-related Domains The Ubiquitin-interacting Motif (UIM) The UEV Domain The GAT Domain Other Ubiquitin-binding Domains Building Complex Systems From Simple Domains Enzymes with Additional Ubiquitin-binding Sites The UbL/UBA Adapter Paradigm Non-orthologous Domain Replacement Outlook