调节器
基因
细胞生物学
基因调控网络
转录因子
计算生物学
转录调控
操纵子
抄写(语言学)
功能(生物学)
出处
期刊:Journal of Molecular Microbiology and Biotechnology
[S. Karger AG]
日期:2002-05-01
卷期号:4 (3): 341-346
被引量:168
摘要
Many bacterial species exhibit a general stress response that can be induced by numerous very different stress conditions and, phenotypically, renders the cells broadly stress resistant. In Escherichia coli ,t his response is dependent on the s S (RpoS) subunit of RNA polymerase. s S is a close relative of the vegetative sigma factor s 70 (RpoD) and recognizes very similar promoter sequences. In recent years, significant progress has been made with respect to elucidating (i) the molecular mechanisms that control the cellular s S level, which include translational regulation as well as intricate control of s S proteolysis, and (ii) the molecular function of s S as a transcription initiation factor, where a number of s S -dependent promoters have been studied in great detail, and the mechanisms that generate s S selectivity are
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