The role of cathepsin G in the diagnosis and immunotherapy of acute myeloid leukemia

Cathepsin G(CG)is one of the serine proteases of neutrophils, and its mRNA is specifically increased in the promyelomonocytic stage of neutrophils and abnormal in several acute myeloid leukemias(AML). Meanwhile, CG is one of AML-associated antigens with strong immunocompetence,it is an important target of immunotherapy in AML. In this paper, the role of CG in the diagnosis and immunotherapy of AML were reviewed. Key words: Cathepsin G; Acute myeloid leukemia; Immunotherapy