Cellular senescence-mediated skin aging

Aging is age-related degeneration of the whole body, and skin aging is one of the most visualized changes in aging. Cellular senescence is a stress response to stable cell cycle arrest, and it is both the hallmark of aging and the important mechanism of the occurrence and development of aging. With the development of skin aging, senescent cells gradually accumulate in both the epidermis and dermis, and further exacerbate aging. Thus, when these senescent cells are eliminated, the aging skin seems to be rejuvenated. Cellular senescence is involved in the process of skin aging, which may be related to activation of DNA damage response pathway, up-regulation of regulatory proteins blocking cell cycle, and increase of senescence-associated secretory phenotypes. Cellular senescence is expected to be a novel target for preventing skin aging in the future. Key words: Skin aging; Cell aging; Senescence-associated secretory phenotype