表观遗传学
DNA甲基化
先天免疫系统
生物
组蛋白
免疫系统
刺激(心理学)
后生
神经科学
细胞生物学
免疫学
DNA
遗传学
基因
基因表达
心理学
心理治疗师
作者
Sarah Sun,Luis B. Barreiro
标识
DOI:10.1016/j.coi.2020.02.002
摘要
Stimulation or infection of innate immune cells induces profound epigenetic changes, including the induction of histone modifications and alterations in DNA methylation levels. While some of these changes are rapidly reversible, others appear to be long-lasting, even in mitotic populations, with important functional consequences for the stimulus-experienced cell. Here we discuss the individual contributions of each of the plethora of known epigenetic modifications to the initial transcriptional response to immune activation, their dynamics as cells return to homeostasis, and their contribution to memory of the initial stimulus.
科研通智能强力驱动
Strongly Powered by AbleSci AI