化学
催化作用
内酰胺
内酯
立体化学
劈理(地质)
转化(遗传学)
分子
组合化学
有机化学
断裂(地质)
生物化学
基因
工程类
岩土工程
作者
Ho Yun Jung,Sukbok Chang,Sungwoo Hong
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-08-16
卷期号:21 (17): 7099-7103
被引量:16
标识
DOI:10.1021/acs.orglett.9b02673
摘要
A new approach has elaborated on the conversion of γ-lactones to the corresponding NH γ-lactams that can serve as γ-lactone bioisosteres. This approach consists of reductive C–O cleavage and an Ir-catalyzed C–H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH γ-lactam building blocks starting from γ-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.
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