Domino Reactions Initiated by Copper‐Catalyzed Aryl‐I Bond Thiolation For the Switchable Synthesis of 2,3‐Dihydrobenzothiazinones and Benzoisothiazolones

Abstract The three‐component reactions of o ‐iodobenzamides, elemental sulfur and dichloromethane (DCM) providing 2,3‐dihydro‐4 H ‐benzo[e][1,3]thiazin‐4‐ones (2,3‐dihydrobenzothiazinones) are accomplished via copper‐catalyzed aryl C−I thiolation and subsequent N ‐, S ‐hetero ring formation. In addition, the in situ aryl C−I bond thiolation is also employed for the switchable synthesis of benzo[d]isothiazol‐3(2 H )‐ones (benzoisothiazolones) by subjecting o ‐iodobenzamides, elemental sulfur to the copper‐catalyzed condition with microwave irradiation. magnified image