红细胞生成
海西定
调节器
无效红细胞生成
串扰
转铁蛋白
贫血
主调节器
铁稳态
医学
内科学
细胞生物学
化学
生物
内分泌学
生物化学
新陈代谢
转录因子
工程类
基因
电子工程
作者
Laura Silvestri,Antonella Nai
标识
DOI:10.1053/j.seminhematol.2021.05.002
摘要
The large amount of iron required for hemoglobin synthesis keeps iron homeostasis and erythropoiesis inter-connected, both iron levels being affected by increased erythropoiesis, and erythropoiesis regulated by serum iron. The connection between these 2 processes is maintained even when erythropoiesis is ineffective. In the last years great advances in the understanding of the mechanisms of this crosstalk have been achieved thanks to the discovery of 2 essential players: hepcidin, the master regulator of iron homeostasis, and erythroferrone, the long sought erythroid regulator. In addition, how circulating transferrin-bound iron contributes to the crosstalk between the 2 systems has started to be unraveled.
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