埃及伊蚊
毒理
载体(分子生物学)
生物
内向整流钾离子通道
钾通道
药理学
伊蚊
病毒学
生态学
登革热
离子通道
生物化学
幼虫
生物物理学
重组DNA
基因
受体
作者
Viktoriya Mashinson,Corey R. Hopkins
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2021-09-30
标识
DOI:10.4155/fmc-2021-0189
摘要
The mosquito continues to be the most lethal animal to humans due to the devastating diseases that it carries and transmits. Controlling mosquito-borne diseases relies heavily on vector management using neurotoxic insecticides with limited modes of action. This has led to the emergence of resistance to pyrethroids and other neurotoxic insecticides in mosquitoes, which has reduced the efficacy of chemical control agents. Moreover, many neurotoxic insecticides are not selective for mosquitoes and negatively impact beneficial insects such as honeybees. Developing new mosquitocides with novel mechanisms of action is a clear unmet medical need; this review covers the efforts made toward this end by targeting the renal inward rectifier potassium channel (Kir) of the mosquito.
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