Cuproptosis-driven reprogramming of fibroblast communication by GK is associated with the immune microenvironment in diabetic foot ulcers

Our data indicate that the cuproptosis-related gene GK is associated with alterations in DFU immune communication through fibroblast-centric networks, as reflected by correlations with immune infiltration and predicted ligand-receptor crosstalk. GK therefore represents a promising candidate diagnostic biomarker and a potential therapeutic target for DFUs that warrants further functional validation.