Temporal and Spatial Scales of Human Resting-state Cortical Activity Across the Lifespan

Sensorimotor and cognitive abilities undergo substantial changes throughout the human lifespan, but the corresponding changes in the functional properties of cortical networks remain poorly understood. This can be studied using temporal and spatial scales of functional magnetic resonance imaging (fMRI) signals, which provide a robust description of the topological structure and temporal dynamics of neural activity. For example, timescales of resting-state fMRI signals parsimoniously predict a significant amount of the individual variability in functional connectivity networks identified in adult human brains. In the present study, we quantified and compared temporal and spatial scales in resting-state fMRI data collected from 2,352 subjects of either sex between the ages of 5 and 100 in Developmental, Young Adult, and Aging datasets from the Human Connectome Project. For most cortical regions, we found that both temporal and spatial scales decreased with age throughout the lifespan, with the visual cortex and the limbic network consistently showing the largest and smallest scales, respectively. For some prefrontal regions, however, these two scales displayed non-monotonic trajectories and peaked around the same time during adolescence and decreased throughout the rest of the lifespan. We also found that cortical myelination increased monotonically throughout the lifespan, and its rate of change was significantly correlated with the changes in both temporal and spatial scales across different cortical regions in adulthood. These findings suggest that temporal and spatial scales in fMRI signals, as well as cortical myelination, are closely coordinated during both development and aging. Significance Statement Temporal and spatial scales of resting-state cortical activity in humans measured by fMRI largely decreased throughout the lifespan, except that for some regions in the prefrontal cortex they peaked similarly during adolescence. In addition, whereas cortical myelination consistently increased throughout the lifespan, its variation across different cortical networks and the rate of age-related changes were correlated with the dynamics of temporal and spatial scales of rs-fMRI activity, suggesting that the spatio-temporal scales of cortical activity and cortical myelination might be co-regulated during development and aging.