ALK Inhibition Prolongs Survival in a Mouse Model of ALK -Positive Anaplastic Thyroid Cancer

Our data demonstrate that the combination of ALK^F1174L mutation with Trp53 loss leads to the development of ATC. This study provides the first functional data supporting the use of ALK inhibitors in patients with ALK-driven ATC. Our novel ATC mouse model and the derived cell lines offer valuable tools to explore the molecular characteristics of ATC, especially signaling pathway activation and tumor microenvironment, and to test novel therapeutics for the treatment of advanced thyroid cancers.