中性粒细胞胞外陷阱
急性胰腺炎
医学
趋化因子
吞噬作用
免疫学
免疫系统
炎症
脱颗粒
先天免疫系统
败血症
胰腺炎
疾病
细胞外
生物
受体
病理
内科学
细胞生物学
作者
Hongxin Kang,Yue Yang,Lv Zhu,Xiaojing Zhao,Juan Li,Wen-Fu Tang,Mei-Hua Wan
标识
DOI:10.1097/cm9.0000000000002359
摘要
Severe acute pancreatitis (SAP) is a life-threatening acute abdominal disease with two peaks of death: the first in the early stage, characterized by systemic inflammatory response-associated organ failure; and the second in the late stage, characterized by infectious complications. Neutrophils are the main immune cells participating in the whole process of SAP. In addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens, neutrophil extracellular traps (NETs) also play an important roles in inflammatory reactions. We reviewed the role of NETs in the occurrence and development of SAP and its fatal complications, including multiple organs injury, infected pancreatic necrosis, and thrombosis. This review provides novel insights into the involvement of NETs throughout the entire process of SAP, showing that targeting NETs might be a promising strategy in SAP treatment. However, precision therapeutic options targeting NETs in different situations require further investigation.
科研通智能强力驱动
Strongly Powered by AbleSci AI