Stereodivergent union of esters and dienes via cooperative Lewis base/palladium catalysis

Access to all possible stereoisomers of prominent structural motifs remains a long-standing challenge for catalyzed C(sp 3 Zhang Q. Zhu M. Zi W. Synergizing palladium with Lewis base catalysis for stereodivergent coupling of 1,3-dienes with pentafluorophenyl acetates. Chem. 2022; 8: 2784-2796https://doi.org/10.1016/j.chempr.2022.07.014 Abstract Full Text Full Text PDF Scopus (13) Google Scholar )–C(sp 3 Zhang Q. Zhu M. Zi W. Synergizing palladium with Lewis base catalysis for stereodivergent coupling of 1,3-dienes with pentafluorophenyl acetates. Chem. 2022; 8: 2784-2796https://doi.org/10.1016/j.chempr.2022.07.014 Abstract Full Text Full Text PDF Scopus (13) Google Scholar ) bond construction. In this issue of Chem, Zi and co-workers describe a stereodivergent isothiourea/palladium cooperative catalysis-based alkylation between esters and dienes. Access to all possible stereoisomers of prominent structural motifs remains a long-standing challenge for catalyzed C(sp 3 Zhang Q. Zhu M. Zi W. Synergizing palladium with Lewis base catalysis for stereodivergent coupling of 1,3-dienes with pentafluorophenyl acetates. Chem. 2022; 8: 2784-2796https://doi.org/10.1016/j.chempr.2022.07.014 Abstract Full Text Full Text PDF Scopus (13) Google Scholar )–C(sp 3 Zhang Q. Zhu M. Zi W. Synergizing palladium with Lewis base catalysis for stereodivergent coupling of 1,3-dienes with pentafluorophenyl acetates. Chem. 2022; 8: 2784-2796https://doi.org/10.1016/j.chempr.2022.07.014 Abstract Full Text Full Text PDF Scopus (13) Google Scholar ) bond construction. In this issue of Chem, Zi and co-workers describe a stereodivergent isothiourea/palladium cooperative catalysis-based alkylation between esters and dienes. Synergizing palladium with Lewis base catalysis for stereodivergent coupling of 1,3-dienes with pentafluorophenyl acetatesZhang et al.ChemAugust 17, 2022In BriefZi et al. describe a synergistic palladium/chiral Lewis base catalysis for the stereodivergent coupling of 1,3-dienes with pentafluorophenyl acetates. All four stereoisomers of the coupling products could be selectively prepared with high diastereo- and enantio-selectivities. Coupled with a late-stage transformation of the pentafluorophenyl moiety, this method provides a general approach to various chiral molecules bearing vicinal stereocenters. Full-Text PDF