对映选择合成
对称化
催化作用
组合化学
化学
基质(水族馆)
合理设计
有机化学
纳米技术
材料科学
海洋学
地质学
作者
Jonas Rein,Soren D. Rozema,Olivia Langner,Samson B. Zacate,Melissa Hardy,Juno C. Siu,Brandon Q. Mercado,Matthew S. Sigman,Scott C. Miller,Song Lin
标识
DOI:10.26434/chemrxiv-2022-8cd9w-v2
摘要
Catalytic enantioselective methods that are general over a broad range of substrates facilitate application in synthetic discovery and development settings; however, truly general catalysts for asymmetric synthesis are rare. Herein, we report a strategy for the oxidative desymmetrization of meso-1,4 diols predicated on a non-traditional optimization protocol utilizing a panel of screening substrates rather than a singular model substrate. Critical to this approach was rational modulation of a peptide sequence incorporating a novel, aminoxyl-based catalytic residue. A general catalyst emerged, providing high selectivity in delivery of enantioenriched lactones across a broad range of diols.
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