光动力疗法
活性氧
光敏剂
自由基清除剂
氧化应激
谷胱甘肽
癌症研究
体内分布
肿瘤微环境
炎症
化学
材料科学
医学
体外
免疫学
生物化学
肿瘤细胞
光化学
酶
有机化学
作者
Muyao Li,Linlin Huo,Jie Zeng,Guifen Zhu,Xiangqing Liu,Xianglong Zhu,Guoming Huang,Yi Wang,Kaiyuan Ni,Zhenghuan Zhao
标识
DOI:10.1002/adhm.202202043
摘要
Photosensitizer in photodynamic therapy (PDT) accumulates in both tumor and adjacent normal tissue due to low selective biodistribution, results in undesirable side effect with limited clinic application. Herein, an intelligent nanoplatform is reported that selectively acts as reactive oxygen species (ROS) scavenger in normal tissue but as ROS generator in tumor microenvironment (TME) to differentially control ROS level in tumor and surrounding normal tissue during PDT. By down-regulating the produced ROS with dampened cytokine wave in normal tissue after PDT, the nanoplatform reduces the inflammatory response of normal tissue in PDT, minimizing the side effect and tumor metastasis in PDT. Alternatively, the nanoplatform switches from ROS scavenger to generator through the glutathione (GSH) responsive degradation in TME, which effectively improves the PDT efficacy with reduced GSH level and amplified oxidative stress in tumor. Simultaneously, the released Mn ions provide real-time and in situ signal change of magnetic resonance imaging (MRI) to monitor the reversal process of catalysis activity and achieve accurate tumor diagnosis. This TME-responsive ROS scavenger/generator with activable MRI contrast may provide a new dimension for design of next-generation PDT agents with precise diagnosis, high therapeutic efficacy, and low side effect.
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