Health Effects of Vitamin D: Evidence from Mendelian Randomization studies v1

Preclinical data and observational studies suggest that vitamin D has wide-ranging skeletal and extra-skeletal effects. However, it remains controversial whether the link between vitamin D and many health outcomes is causal or not. Mendelian randomization (MR) provides an alternative approach to facilitate causal inference in an observational setting. Here, we will systematically summarize and evaluate the evidence on vitamin D and various health outcomes from MR studies.