藤黄酸
三阴性乳腺癌
介孔材料
材料科学
纳米技术
癌症
乳腺癌
化学
医学
有机化学
内科学
生物化学
催化作用
体外
作者
Jiaqi Liu,Hongmei Li,Shan Huang,Hong Peng,Jiamei Li,K. N. Tu,Siyu Tan,Rou Xie,Lei Lei,Yuwen Qin,Huile Gao,Lulu Cai
出处
期刊:Small
[Wiley]
日期:2024-03-06
标识
DOI:10.1002/smll.202309583
摘要
Abstract Triple‐negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, characterized by aggressiveness and high recurrence rate. As monotherapy provides limited benefit to TNBC patients, combination therapy emerges as a promising treatment approach. Gambogic acid (GA) is an exceedingly promising anticancer agent. Nonetheless, its application potential is hampered by low drug loading efficiency and associated toxic side effects. To overcome these limitations, using mesoporous polydopamine (MPDA) endowed with photothermal conversion capabilities is considered as a delivery vehicle for GA. Meanwhile, GA can inhibit the activity of heat shock protein 90 (HSP90) to enhance the photothermal effect. Herein, GA‐loaded MPDA nanoparticles (GA@MPDA NPs) are developed with a high drug loading rate of 75.96% and remarkable photothermal conversion performance. GA@MPDA NPs combined with photothermal treatment (PTT) significantly inhibit the tumor growth, and effectively trigger the immunogenic cell death (ICD), which thereby increase the number of activated effector T cells (CD8 + T cells and CD4 + T cells) in the tumor, and hoist the level of immune‐inflammatory cytokines (IFN‐ γ , IL‐ 6 , and TNF‐ α ). The above results suggest that the combination of GA@MPDA NPs with PTT expected to activate the antitumor immune response, thus potentially enhancing the clinical therapeutic effect on TNBC.
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