Apart and back again: Reestablished neuronal connections restore walking after paralysis

Despite significant strides promoting axon regeneration after spinal cord injury (SCI), meaningful functional recovery remains elusive. Using a combination of approaches, Squair et al. 1 Squair J.W. Milano M. de Coucy A. Gautier M. Skinnider M.A. James N.D. Cho N. Lasne A. Kathe C. Hutson T.H. et al. Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023; 381: 1338-1345 Crossref Scopus (3) Google Scholar elegantly demonstrate that axons damaged after SCI must be reconnected with their natural targets to recover lost neurological functions. Despite significant strides promoting axon regeneration after spinal cord injury (SCI), meaningful functional recovery remains elusive. Using a combination of approaches, Squair et al. 1 Squair J.W. Milano M. de Coucy A. Gautier M. Skinnider M.A. James N.D. Cho N. Lasne A. Kathe C. Hutson T.H. et al. Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023; 381: 1338-1345 Crossref Scopus (3) Google Scholar elegantly demonstrate that axons damaged after SCI must be reconnected with their natural targets to recover lost neurological functions.