In vitro Antibacterial Effect of Hesperidin Microemulsion to Staphylococcus aureus and Listeria monocytogenes

Foodborne bacterial infections and intoxications constitute a large proportion of bacterial diseases worldwide. In recent years, there has been an increasing resistance to chemotherapeutics used in the treatment of these diseases. Studies have shown that some compounds extracted from natural products and plants have alternative potential to antibiotics. In this study, it was aimed to reveal the antimicrobial potential of hesperidin microemulsion on Listeria monocytogenes and Staphylococcus aureus. In the study, the broth microdilution method was used to demonstrate in vitro antimicrobial activity. In the microdilution test, the MIC values of hesperidin for S. aureus and L. monocytogenes were as 128 μg/mL. In comparison, the MIC values of ampicillin for S. aureus and L. monocytogenes were as 0.5 μg/mL. Hesperidin is a compound with biologically valuable properties. Its antimicrobial effect may open a promising field as an alternative to antibiotics. However, detailed studies on hesperidin and similar potential active substances are needed to fully understand its therapeutic potential and to define its mechanisms of action.