创伤弧菌
粪肠球菌
枯草芽孢杆菌
海绵
弧菌
金黄色葡萄球菌
立体化学
抗菌活性
大肠杆菌
圆二色性
铜绿假单胞菌
化学
微生物学
生物
细菌
生物化学
植物
遗传学
基因
作者
Hao‐Bing Yu,Bo Hu,Guanghui Wu,Z. Ning,Ying He,Binghua Jiao,Xiao-Yu Liu,Hou-Wen Lin
标识
DOI:10.1021/acs.jnatprod.3c00218
摘要
Phyllospongianes A-E (1-5), five new scalarane derivatives featuring an unprecedented 6/6/6/5 tetracyclic dinorscalarane scaffold, along with the known probable biogenetic precursor, 12-deacetylscalaradial (6), were isolated from the marine sponge Phyllospongia foliascens. The structures of the isolated compounds were determined by analysis of spectroscopic data and electronic circular dichroism experiments. Compounds 1-5 are the first 6/6/6/5 tetracyclic scalarane derivatives to be reported within the scalarane family. Compounds 1, 2, and 4 exhibited antibacterial activity against Vibrio vulnificus, Vibrio parahemolyticus, Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, and Pseudomonas aeruginosa with MIC values ranging from 1 to 8 μg/mL. Furthermore, compound 3 exhibited significant cytotoxic activity on MDA-MB-231, HepG2, C4-2-ENZ, MCF-7, H460, and HT-29 cancer cell lines with IC50 values in the range between 0.7 and 13.2 μM.
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