纳米团簇
对映体药物
手性(物理)
结晶
反离子
材料科学
正交晶系
结晶学
纳米技术
化学
晶体结构
对映选择合成
有机化学
离子
手征对称破缺
物理
催化作用
夸克
Nambu–Jona Lasinio模型
量子力学
作者
Along Ma,Wenjun Du,Jingping Wang,Kefan Jiang,Zixue Cheng,Wenjie Sheng,Haiyan Zheng,Rongchao Jin,Shuxin Wang
标识
DOI:10.1021/acs.jpclett.3c00794
摘要
Chirality has risen as an attractive topic in materials research in recent years, but the attainment of enantiopure materials remains a major challenge. Herein, we obtained homochiral nanoclusters by a recrystallization strategy, without any chiral factors (i.e., chiral ligands, counterions, etc.). Through the rapid flipping of configuration of silver nanoclusters in solution, the initial racemic Ag40 (triclinic) nanoclusters are converted to homochiral (orthorhombic) as revealed by X-ray crystallography. In the seeded crystallization, one homochiral Ag40 crystal is used as a seed to direct the growth of crystals with specific chirality. Furthermore, enantiopure Ag40 nanoclusters can be used as amplifiers for the detection of chiral carboxylic drugs. This work not only provides chiral conversion and amplification strategies to obtain homochiral nanoclusters but also explains the chirality origin of nanoclusters at the molecular level.
科研通智能强力驱动
Strongly Powered by AbleSci AI